ACMS Colloquium: Mathematical and Computational Modeling of Cancer Stem Cells in Tumor Growth

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Location: 127 Hayes-Healy Center

enderling

Heiko Enderling, Assistant Professor at Tufts University School of Medicine, will give a colloquium titled, "Mathematical and Computational Modeling of Cancer Stem Cells in Tumor Growth."

The cancer stem cell hypothesis postulates that only a subpopulation of cancer cells in a tumor is capable of initiating, sustaining and re-initiating tumors, leaving the bulk of the population being non-stem cancer cells that lack tumor initiation and progression potential. We develop mathematical and computational models of the interaction of these two phenotypically distinct populations, and observe that the emerging tumor population can exhibit various non-linear growth kinetics. An environmentally independent dormant state is an inevitable early tumor progression bottleneck for a large range of biologically realistic cell kinetic parameters. When intrinsic cell kinetics combine in unexpected manner, escape to tumor progression occurs as morphologically distinct self-metastatic expansion  of multiple self-limited tumor clones. We show how numerical results from the model also further our understanding of how the fraction of cancer stem cells in a solid tumor evolves.

Abstract

Originally published at acms.nd.edu.