Jeffrey Aubé
University of Kansas
“New Heterocyclic Chemistry: Methods, Libraries and Biology”
A primary goal of chemical biology is to provide new chemical matter for screening and other biological applications. One way to accomplish this is to develop new synthetic methods that provide attractive routes to small molecules. The Aubé laboratory has a long-standing interest in developing new reactions, notably those involving alkyl azides. This seminar will show how such synthetic methodology work is applied to the total synthesis of biologically active natural products and compound libraries. Our interest also extends to applying synthesis for the development of biological probes and drug leads in areas such as cancer, infectious disease, and neuroscience. Selected examples will be provided.
Originally published at chemistry.nd.edu.