Ruedi Aebersold, Ph.D.
Department Head of Biology at the Institute of Molecular Systems Biology
141 DeBartolo Hall – 1:00 pm
April 8, 2016
Aebersold is a native of Switzerland and earned his Ph.D. in Cellular Biology at the Biocenter of the University of Basel in 1983. He was a faculty member at the University of Washington and the University of British Columbia until 2000 when he co-founded the Institute for Systems Biology in Seattle. In 2004, he accepted a position as full professor at the Institute of Biotechnology at the Swiss Federal Institute of Technology (ETH) in Zurich, where in 2005 his research group became the first integral part of the newly founded Institute of Molecular Systems Biology. He serves on numerous scientific advisory committees and is a member of several editorial boards in the fields of protein science, genomics, and proteomics.
Michael Dennin, Ph.D.
Professor of Physics and Astronomy
University of California Irvine
105 Jordan Hall – 7:00pm
February 17, 2016
Michael Dennin is professor of physics and astronomy at University of alifornia, Irvine. He earned his A.B. from Princeton University, and his M.A. and Ph.D. (1995) from the University of California, Santa Barbara. He held a postdoctoral position at the University of California, Los Angeles. He is an Alfred P. Sloan Research Fellow and a Research Corporation Cottrell Scholar. Professor Dennin is well-known for popularizing science for the public. He has taught many online courses on the nature of science, including team teaching a MOOC based on the television program The Walking Dead. He has appeared on a number of television programs, including Spiderman Tech, Batman Tech, Star Wars Tech and Ancient Aliens
Alexander S. Raikhel, Ph.D.
Mir S. Mulla Chair in Entomology
University of California Riverside
"Regulatory Cascades Controlling Mosquito Reproduction" (897kb PDF)
283 Galvin Life Sciences – 4:00 p.m.
December 7, 2015
Mosquitoes rely on blood for nutrition, putting them in position to transmit some of the world’s deadliest diseases, like malaria and Dengue fever. Alexander S. Raikhel, elected to the National Academy of Sciences in 2009, believes that preventing the mosquito from carrying the pathogen in the first place is the key to vector control. Raikhel has been studying the connection between blood meals and egg production in Aedes aegypti in hopes of co-opting egg production signals to activate the mosquito’s immune system against incoming pathogens. In his Inaugural Article, Raikhel, a distinguished professor at the University of California, Riverside continues an investigative strategy that has served him well throughout his career: using the latest research in established model organisms to hammer out methods for the mosquito, this time looking for microRNAs active in the egg production cycle.
Hans Clevers, Ph.D.
Professor of Molecular Genetics
Hubrecht Institute, Utrecht, Netherlands
105 Jordan Hall – 4:00 p.m.
November 23, 2015
Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. He worked as a postdoc (1986-1989) with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University.
From 1991-2002, he was a Professor in Immunology at the University Utrecht and a Professor in Molecular Genetics since 2002. From 2002-2012, he was the Director of the Hubrecht Institute. From 2012-2015, he was the President of the Royal Netherlands Academy of Arts and Sciences (KNAW). Professor Clevers began serving as the Director of Research of the Princess Maxima Center for Pediatric Oncology in June, 2015. He is the recipient of several prestigious scientific awards, as well as earning Chevalier de la Legion d’Honneur (2005) and Knight in the Order of the Netherlands Lion (2012). He is also a member of both the Royal Netherlands Academy of Arts and Sciences and the National Academy of Sciences of the USA.
Dr. Clevers’ research is focused on healthy and diseased intestines. He discovered and delineated some of the most fundamental molecular signaling processes that drive normal development of the gut and linked these to diseases, such as cancer. In recent years, he was the first, and foremost, discoverer of the intestinal stem cell niche. He also succeeded in growing “mini intestines” in cell culture. Professor Clevers’ scientific contributions can be counted among the most important in biomedicine of his generation and have a fundamental impact on both regenerative medicine and cancer treatment.
Trudy F. C. Mackay, Ph.D.
Program in Genetics, Department of Biological Sciences
W.M. Keck Center for Behavioral Biology
North Carolina State University
101 DeBartolo Hall – 4:00 p.m.
October 14, 2015
Quantitative traits are affected by multiple interacting loci with individually small and environmentally sensitive effects. Knowledge of the detailed genetic architecture of quantitative traits is important from the perspectives of evolutionary biology, human health, and plant and animal breeding. Understanding the genetic architecture of quantitative traits begins with identifying the genes regulating these traits, mapping the subset of genetically varying quantitative trait loci (QTLs) in natural populations, and pinpointing the molecular polymorphisms defining QTL alleles. Drosophila brings an impressive toolkit to the challenge of genetically dissecting quantitative traits.
In this talk, Mackay will discuss insights into the complex genetic architecture of organismal and gene expression quantitative traits obtained from analyses of new mutations and genome wide association mapping in the Drosophila melanogaster Genetic Reference Panel (DGRP), which consists of 205 sequenced inbred lines derived from the Raleigh, USA population. These studies indicate that epistatic gene action is common, and additivity can be an emergent property of underlying genetic interaction networks. Epistasis causes hidden quantitative genetic variation in natural populations, the potential for rapid speciation, and negatively impacts the predictive ability of additive models. These observations offer valuable lessons for understanding the genetic basis of variation for quantitative traits in other organisms.
David J. Wineland, Ph.D.
National Institute of Standards and Technology
"Quantum computers and raising Schrödinger’s cat" (437kb PDF)
Carey Auditorium, Hesburgh Library – 4:00 p.m.
March 18, 2015
David J. Wineland is a Nobel-laureate physicist at the National Institute of Standards and Technology, Time and Frequency Division in Boulder, Colo. He was awarded the Nobel Prize in Physics with Sergi Haroche for “groundbreaking experimental methods that enable measuring and manipulation of individual quantum systems.” He is a fellow of the American Physical Society, the American Optical Society, and was elected to the National Academy of Sciences in 1992. A highly decorated scientist, Wineland earned the National Medal of Science in the engineering sciences in 2007.
Roel Nusse, Ph.D.
Professor of Developmental Biology, Virginia and Daniel K. Ludwig Professor of Cancer Research
Investigator, Howard Hughes Medical Institute, Stanford University
"Wnt Signaling and Stem Cell Control" (408kb PDF)
101 Jordan Hall of Science – 12:30 p.m.
October 31, 2014
Roel Nusse’s laboratory is interested in the growth, development and integrity of animal tissues. They study different organs to identify common principles, which they extend to understand processes underlying cancer and injury repair. In most organs, stem cells generate the specialized cell types, but they also self-renew to maintain the tissue. An optimal balance between the number of stem and differentiated cells is essential for proper organ function. Locally acting signals from stem cell niches are important to maintain this balance in a spatially organized manner, and these signals are key to understanding the regulation of growth.
A major focus of the Nusse lab is Wnt signaling, which is essential for regulating stem cells. How this is achieved is far from clear and is the subject of studies in the lab, both in vivo and in cell culture. The types of questions that the Nusse lab investigates are: What role do Wnt-responsive cells play in tissue maintenance and regeneration? How is the expression of Wnt signals regulated, in normal and injured tissues? Does oriented Wnt signaling polarize asymmetrically dividing stem cells, which plays a central role in tissue homeostasis and regeneration.
Scott Hultgren, Ph.D.
Helen L. Stoever Professor of Molecular Microbiology
Director of the Center for Women's Infectious Disease Research
Washington University School of Medicine
283 Galvin Life Sciences Center – 4:00 p.m.
March 18, 2014
Hultgren’s research utilizes genetic, molecular, biochemical, and structural biology to understand the molecular mechanisms behind bacterial pathogenesis.
Juan Maldacena, Ph.D.
Professor, Institute for Advanced Study, Princeton
"Strings, gauge theories and gravity" (1.2MB PDF)
127 Nieuwland Science Hall – 4:00 p.m.
November 6, 2013
Gauge theories, such as the one describing strong interactions, contain string-like excitations.
String theory is a theory describing the quantum dynamics of strings. The simplest versions of string theory live in a ten-dimensional space time. Maldacena will explain how these strings are intimately connected to the strings that appear in four-dimensional gauge theories.
The four dimensional gauge theory gives rise to a string-like excitation that lives in ten dimensions. The ten-dimensional space is curved in such a way that its quantum dynamics is equivalent to that of a four-dimensional quantum field theory. This relation is useful to understand strongly interacting gauge theories. It can also be used to explain some quantum aspects of black holes.
Maldacena's research focuses on quantum gravity, string theory, and quantum field theory. He has proposed a relationship between quantum gravity and quantum field theories that elucidates various aspects of both theories. He is studying this relationship further in order to understand the deep connection between black holes and quantum field theories, and he is also exploring the connection between string theory and cosmology.
Richard Connell, Ph.D
Vice President of External Research Solutions, Global Research and Development
127 Nieuwland Science Hall – 4:00 p.m.
September 27, 2013
Dr. Connell is honored for his achievements in pharmaceutical research and development as well as his accomplishments as a leader at two of the world’s largest pharmaceutical companies: Bayer and Pfizer.
Advised by Prof. Paul Helquist, Dr. Connell received his Ph.D. in organic chemistry from Notre Dame in 1989—also the year in which he won the Notre Dame Outstanding Graduate Student Award. He then began a two-year National Institutes of Health postdoctoral fellowship at Harvard University under Professor E.J. Corey.
In 1990, Dr. Connell joined the new Bayer Pharmaceutical Research Center in West Haven, Connecticut, where he spent nine years and rose to the position of director of Diabetes and Obesity Chemistry.
Dr. Connell joined Pfizer in 1999 as Director of Cancer Chemistry. He was an inventor on one of the two key patents for the drug now known as Tarceva®, which is has been shown to improve overall survival in advanced non-small cell lung cancer and advanced pancreatic cancer. He then became Pfizer’s Executive Director of Research operations and, next, the Vice President of External Research Solutions Center of Excellence (ERS). In 2011, Dr. Connell moved to Shanghai for a one- year assignment to help Pfizer establish the Anti-infective Research Unit. He returned to the States in early 2012 and continues to lead ERS and manage Pfizer’s network of research partners around the globe.
Serap Aksoy, Ph.D.
Keynote Speaker for the 7th annual Arthropod Genomics Symposium and Vector Base Workshop (194kb PDF).
June 12, 2013
The conference is designed for scientists interested in genomic studies of arthropods, both model organisms and those of agricultural or health relevance. The symposium and workshop are hosted by the Eck Institute for Global Health.
S. James Gates, Jr., Ph.D.
University System of Maryland Regents Professor, John S. Toll Professor of Physics, and Center for String & Particle Theory Director
2011 National Medal of Science Recipient
"The ABEGHHK'tH Revolution" (575kb PDF)
101 Jordan Hall of Science – 7:00 p.m.
April 29, 2013
The observation by CERN, the European Organization for Nuclear Research, of the Higgs boson was hailed as one of the most significant scientific events of recent times. What is the Higgs boson, why is it so important, and what does the observation of this particle mean for our understanding of the universe? These questions and more will be addressed in this lecture.
Midwest Ecology and Evolution Conference
March 23-24, 2013
Miami University of Ohio
Mike Vanni is a professor at Miami University of Ohio in the department of Zoology and in the Graduate Program in Ecology, Evolution and Environmental Biology. He uses a variety of techniques from whole ecosystem studies to laboratory experiments to simulation modeling to examine questions in aquatic ecology relating to food webs, nutrient and carbon cycling, and watershed-lake interactions. His current research focuses on the role of animals in nutrient cycling, including variation among species using ecological stoichiometry and metabolic ecology as conceptual frameworks; how the importance of animal-mediated nutrient cycling varies among biomes; and how animals can function as nutrient sources or sinks. Another aspect of this research examines how the role of fish in nutrient cycling varies over temporal scales and among lakes with contrasting watershed land use.
Rowan Barrett is an NSERC Banting fellow at the Department of Organismic and Evolutionary Biology at Harvard University. His work is motivated by a desire to understand the genetic basis of adaptation to changing environments. His research bridges theoretical and empirical approaches in population genetics, evolutionary ecology, and molecular biology to ask questions about the reciprocal interactions between ecological and evolutionary processes. He has pursued this research program with a variety of key study systems, including stickleback fish, deer mice, and microbes.
Visit the MEEC website for more information.
Inventor, author, and student
Notre Dame Conference Center, McKenna Hall – 7:00 p.m.
March 18, 2013
William Kamkwamba is a Malawian inventor, author and student. After being forced to drop out of school because his family could not afford tuition, he regularly visited his village's library. There, he found the book Using Energy and discovered a picture and explanation of windmills. He gained fame in his country when he built a windmill to power a few electrical appliances in his family's house using parts collected in a local scrap yard in 2002. Since then, he has built a solar-powered water pump that supplies the first drinking water in his village.
His story is told in The Boy Who Harnessed the Wind: Creating Currents of Electricity and Hope and was published in 2009. Kamkwamba is one of four recipients of the 2010 GO Ingenuity Award, a prize awarded to inventors, artists, and makers to promote the sharing of their innovations and skills with marginalized youth in developing nations.
Currently, he is a student at Dartmouth College, Class of 2014.
A book signing and reception will follow the presentation. This event is free and open to the public.
This lecture is also sponsored by the Energy Lecture Series, College of Engineering Edison Lecture Series, cSEND, Center for Social Concerns, Reilly Center, College of Arts and Letters and Office of Sustainability.
This event is organized in partnership with Malawi Matters.
Thomas Franklin O'Meara, O.P.
William K. Warren Emeritus Professor of Theology
105 Jordan Hall of Science – 5:30 p.m.
November 15, 2012
Albert the Great, teacher of Thomas Aquinas, was an important thinker in both science and theology in the Middle Ages. He introduced a new realism (Aristotle) into Western intellectual life. He worked to correct political violence and ecclesiastical corruption. In his decades of teaching and writing, he drew on the writings of Jewish and Muslim philosophers as well as on Greek Christian theologians. He described the natural sciences and theological reflection on Christian faith as independent academic fields and yet capable of dialogue with each other.
A past president of the Catholic Theological Society of America, Thomas F. O’Meara, O.P. continues to teach part-time at Notre Dame, Loyola University (Chicago), and the Catholic Theological Union (Chicago). He has been a visiting professor at Wartburg Lutheran Seminary, St. Joseph’s Theological Institute (Cedara, South Africa), the University of San Diego, and Boston College.
Among his fifteen books are: Theology of Ministry; Thomas Aquinas, Theologian; God in the World: A Guide to Karl Rahner’s Theology. And just published in 2012, Vast Universe. Extraterrestrials and Christian Revelation.
Brian Schmidt, Ph.D.
2011 Nobel Prize Winner in Physics for the discovery of the accelerating expansion of the universe through observations of distant supernovae
February 27, 2012
In 1998, two teams traced back the expansion of the universe over billions of years and discovered that it was accelerating, a startling discovery that suggests that more than 70% of the cosmos is contained in a previously unknown form of matter, called Dark Energy. His work on the accelerating universe was awarded the 2011 Nobel Prize in Physics, jointly with Adam Riess and Saul Perlmutter. Schmidt, who led the High-Redshift Supernova Search Team, will describe this discovery and explain how astronomers have used observations to trace our universe’s history back more than 13 billion years, leading them to ponder the ultimate fate of the cosmos.
Jack Dixon, Ph.D.
Vice President and Chief Scientific Officer of the Howard Hughes Medical Institute.
“Protein Thyrosine Phosphates: Their Roles in Health and Disease”
September 29, 2011
Patrice Courvalin, M.D.
Professor at the Institu Pasteur in Paris, France. Director of the French National Reference Center for Antibiotics and is the Head of the Antibacterial Agents Unit.
Radiation Lab Auditorium – 2:00 p.m.
September 21, 2011
Patrice Courvalin, M.D., is a professor at the Institut Pasteur where he directs the French National Reference Center for Antibiotics and is the Head of the Antibacterial Agents Unit. He is an expert in the genetics and biochemistry of antibiotic resistance in bacteria. In particular, he and his collaborators first described and then elucidated vancomycin resistance in Enterococcus. His research has led to a revision of the dogma describing natural dissemination of antibiotic-resistance genes. He and his colleagues demonstrated that a wide variety of pathogenic bacteria can promiscuously exchange the genetic material conferring antibiotic resistance, proved that conjugation could account for dissemination of resistance determinants between phylogenetically remote bacteria, elucidated the transposition mechanism of conjugative transposons from Gram-positive cocci, and most recently, has obtained direct gene transfer from bacteria to mammalian cells. His work is reported in more than 290 publications in international scientific journals.
Laurent Lafforgue, Ph.D.
2002 Fields Medal recipient and profeseur permanent at the Institut des Hautes Éstudes Scientifiques in Buressur-Yvette, France.
101 Jordan Hall of Science – 4:00 p.m.
May 20, 2011
Laurent Lafforgue is professeur permanent at the Institut des Hautes Études Scientifiques in Bures-sur-Yvette, France. He is a Member of the French Academy of Sciences and a Chevalier de la Légion d’Honneur. In 2002, he was awarded a Fields Medal at the International Congress of Mathematicians in Beijing for his work related to the Langlands program in number theory. He is the recipient of numerous awards, including the Clay Research Prize and the Grand Prix Jacques Herbrand de l’Académie des Sciences.
Chris Quigg, Ph.D.
2011 Sakurai Prize of the American Physical Society and member of the Theoretical Physics Department at the Fermi National Accelerator Laboratory in Batavia, Illinois.
101 DeBartolo Hall – 7:00 p.m.
May 6, 2011
Chris Quigg is co-winner of the 2011 Sakurai Prize of the American Physical Society. His work ranges over many topics in particle physics, from electro-weak symmetry breaking and super collider physics to heavy quarks and the strong interaction among them to ultrahigh-energy neutrino interactions. The essential interplay between theory and experiment is a guiding theme. Because we cannot hope to advance without new instruments, he has devoted much energy to helping to define the future of particle physics—and the new accelerators that will take us there.
Richard R Ernst, Ph.D.
1991 Nobel Prize Winner in Chemistry for his contribution of Fourier Transform nuclear magnetic resonance spectroscopy and the subsequent development of multi-dimensional NMR techniques.
McKenna Hall – 10:00 a.m.
April 7, 2011
NMR has gone through quite a remarkable development. Starting from a curious physics experiment, of apparently little practical usage, it became one of the most powerful analytical tools of science with applications that proved to be indispensable in chemistry, biology, and medicine. Indeed, its growing importance is well recognized by the Nobel Committees in Stockholm. Already eight Nobel Prizes were awarded for achievements in NMR. Additional Nobel Prizes have been given to scientists for work that proved to be seminal for NMR. Several Nobel Laureates who significantly contributed to NMR received their prizes for innovations in other fields. This lecture traces the various contributions of those who have been honored by a Nobel Prize, as well as mentioning some of those who have equally deserved receiving this honor.
Jaques Arnould, Ph.D.
Ethics advisor to the French Space Agency Center National d’Études Spatiales (CNES).
101 Jordan Hall of Science
March 2, 2011
Jacques Arnould is the French Space Agency (CNES) expert in charge of ethical, social and cultural aspect of space activities. His research fields are life and its evolution, space and its conquest. He has written 14 books on life and evolution. The Académie Française has awarded him the 2004 La Bruyére Prize, in the Literature & Philosophy category, for his book "The Devil's Whiskers" published by Editions du Cerf in 2003. He has a Ph.D. in history of science as well as a PhD in theology. His publications include: Les Avatars du géne (en collaboration avec Pierre–Henri Gouyon et Jean–Pierre Henry), Belin, 1997; La Théologie aprés Darwin, Cerf, 1998; Pierre Teilhard de Chardin, Perrin, 2005; Dieu versus Darwin. Les créationnistes vont–ils triompher de la science?, Albin Michel, 2007.
Richard M. Caprioli, Ph.D.
Stanley Cohen Professor of Biochemistry and the Director of the Mass Spectrometry Research Center at Vanderbilt University School of Medicine and Professor in the Departments of Chemistry, Medicine and Pharmacology at Vanderbilt University.
“Advances in Biomolecular Discovery through Mass Spectrometry”
September 2, 2010
“Imaging Mass Spectrometry – Looking Beyond Classical Histology”
September 3, 2010
Richard M. Caprioli is the Stanley Cohen Professor of Biochemistry and Director of the Mass Spectrometry Research Center at Vanderbilt University School of Medicine. He is also currently Professor in the Departments of Chemistry, Medicine and Pharmacology at Vanderbilt University. Dr. Caprioli received his B.S. in 1965 from Columbia University in New York, N.Y., his Ph.D. in 1969 in Biochemistry, also at Columbia University with Professor David Rittenberg. He did a one-year postdoctoral fellowship at Purdue University with Professor John H. Beynon. In 1970, he was appointed as Assistant Professor of Biochemistry at Purdue. In 1975, Dr. Caprioli moved to the University of Texas Medical School in Houston where he was Professor of Biochemistry and Molecular Biology and Director of the Analytical Chemistry Center until his move to Nashville in early 1998.
Mario Capecchi, Ph.D.
2007 co-winner of the Nobel Prize in Physiology & Medicine for discovering a method to create mice in which a specific gene is turned off.
“Modeling Human Cancer in the Mouse”
101 Jordan Hall of Science – 4:00 p.m.
“The Making of a Scientist: An Unlikely Journey”
101 Jordan Hall of Science – 7:00 p.m.
April 7, 2009
Dr. Capecchi has conducted pioneering work in both genetics and cancer research. He is best known for the development of "knockout mice" technology, a gene-targeting technique that has revolutionized the study of mammalian biology and allowed the creation of animal models for hundreds of human diseases, including the modeling of cancers in the mouse. In recognition of his research, Dr. Capecchi was awarded the Nobel Prize in Physiology & Medicine in 2007.
John Mather, Ph.D.
2006 co-winner of the Nobel Prize in Physics for the discovery of the blackbody form and anisotrophy of the cosmic microwave background radiation.
101 Jordan Hall of Science – 7:00 p.m.
April 22, 2009
The history of the Universe in a nutshell, from the Big Bang to now, and on to the future – John Mather will tell the story of how we got here, how the Universe began with a Big Bang, how it could have produced an Earth where sentient beings can live, and how those beings are discovering their history.
Mather was Project Scientist for NASA’s Cosmic Background Explorer (COBE) satellite, which measured the spectrum (the color) of the heat radiation from the Big Bang, discovered hot and cold spots in that radiation, and hunted for the first objects that formed after the great explosion. He will explain Einstein’s biggest mistake, show how Edwin Hubble discovered the expansion of the Universe, how the COBE mission was built, and how the COBE data support the Big Bang theory.
He will also show NASA’s plans for the next great telescope in space, the James Webb Space Telescope. It will look even farther back in time than the Hubble Space Telescope, and will look inside the dusty cocoons where stars and planets are being born today. Planned for launch in 2013, it may lead to another Nobel Prize for some lucky observer.
Mather is a Senior Astrophysicist in the Observational Cosmology Laboratory at NASA’s Goddard Space Flight Center. His research centers on infrared astronomy and cosmology. Mather graduated with a Ph.D. in Physics from the University of California at Berkeley in 1974 with a 4.0 GPA. Mather and George F. Smoot share the 2006 Nobel Prize in Physics for their discovery of the blackbody form and anisotropy of the cosmic microwave background radiation.