A research team led by the University of Notre Dame is working to cut the test time for disease biomarkers.
Brad, the Emil T. Hofman Professor of Chemistry and Biochemistry, is a recognized leader in the field of supramolecular chemistry applied to biological systems. In particular, he designs molecular imaging probes for detecting cancer, cell death, and microbial infection in living organisms. He is founding Director of the Notre Dame Integrated Imaging Facility, a state-of-the-art research resource that provides an integrated suite of sophisticated microscopes and imaging stations for Notre Dame science and engineering researchers.Hearty congratulations to Graham Lappin and Brad Smith who were named Fellows of the Royal Society of Chemistry this past year. Graham, who has been a faculty member since 1982, is a mechanistic inorganic chemist who specializes in electron-transfer and atom-transfer reactions. As Department Chair from 1993-2002 and again from 2005-2009, he oversaw the growth of many facets of the department. Under his leadership we expanded the research enterprise, increased faculty numbers, grew the graduate program, and improved our facilities. He is an enthusiastic and dedicated teacher. Graham has also mined the pop culture vein, having long been mythologized as the inspiration for the voice of “Shrek”.
Congratulations are also in order for Marv Miller and Tony Trozzolo who received alumni awards their former institutions. Marv, who received a B.S. in chemistry from North Dakota State University, was selected as recipient of the 2012 Henry L. Bolley Academic Achievement Award by the North Dakota State University Alumni Association. You can read more about Marv in “The Benchmark” section of this newsletter. Tony, who is the Charles L. Huisking Professor Emeritus of Chemistry, was named the recipient of the 2012 University of Chicago Professional Achievement Award from the Alumni Board of Governors. Tony received a master’s degree and a Ph.D. in chemistry from the University of Chicago prior to embarking on a long and distinguished career in industry and academia in the field of photochemistry.
Two of our analytical chemists have garnered prestigious plaudits. First, Paul Bohn, Arthur J. Schmitt Professor of Chemical and Biomolecular Engineering and joint Professor of Chemistry and Biochemistry, has been designated a Fellow of the Society by the Society for Applied Spectroscopy (SAS). Paul is leading the charge in chemical measurement science, designing and building instruments with the requisite precision to control mass-limited samples in space and time on the nanometer length scale with the goal of applying these devices as sensors or in molecular separations. Norm Dovichi, Grace-Rupley Professor of Chemistry, has been announced as the recipient of the 2012 Robert Boyle Prize for Analytical Science. This biennial prize, given by the Royal Society of Chemistry, includes a £5,000 cash award, a medal, and a lecture tour of the UK. Norm’s research group was partially responsible for developing capillary array electrophoresis with laser-induced fluorescence detection in a sheath flow cuvette—the primary instrument used by the Human Genome Project in its successful effort to determine sequence the human genome. Norm and his group have now set their sites on studying protein expression in single cells in order to determine how, for instance, the proteome changes across a cellular population during cancer progression and during the development of an embryo.
One of our junior faculty, Franklin Tao, has been selected as the 2012 recipient of the Paul H. Holloway Young Investigator Award by the American Vacuum Society (AVS), Thin Film Division. Franklin will present an honorary lecture at the upcoming International Symposium of the AVS. Franklin also authored a book with Steve Bernasek, Functionalization of Semiconductor Surfaces. Published by John Wiley & Sons, Inc., it’s available in both hardcopy and electronic copy
A textbook has also surfaced from our faculty ranks. Authored by Ken Kuno and entitled Introductory Nanoscience Physical and Chemical Concepts, the book is aimed at upper-level undergraduate and graduate students and asks key questions about the quantitative concepts that underlie the fast-emerging nanoscience field. It’s published by Garland Science.
Teaching is a tremendous strength in our department and we were happy to see associate professors Steve Corcelli and Holly Goodson receive Rev. Edmund P. Joyce, C.S.C., Awards for Excellence in Undergraduate Teaching. The awardees, 20 of which are recognized each year, are selected through a process that involves peer and student nominations. Holly is also the recipient of the 2012 Thomas P. Madden Award, recognizing exceptional teaching of first-year students. Beginning in 2005, Holly helped develop and refine a one-semester course for first-year engineering students. Called General Chemistry: Fundamental Principals and Biological Processes, it provides our fledgling engineers with a firm foundation in the biological aspects of chemistry.
Other members of our faculty that were formally recognized with prestigious University awards include Shahriar Mobashery, Navari Family Professor of Life Sciences. Shahriar was the recipient of the 2012 Research Achievement Award. He is internationally known for his work on drug-resistant bacteria and diseases of the extracellular matrix. Brian Baker was awarded the 2012 Director of Graduate Studies Award. He has been instrumental in growing the graduate program and improving its programmatic elements.
The Benchmark: 7 questions for Professor Marvin Miller. George and Winifred Clark Professor of Chemistry and Biochemistry [photo of Marv]
Biography: Marv Miller, the George and Winifred Clark Professor of Chemistry and Biochemistry, received his B.S. from North Dakota State University in 1971 and his Ph.D. from Cornell University in 1976. He spent two years as an NIH postdoctoral fellow at the University of California, Berkeley prior to joining the department in 1977. He and his coworkers focus on new synthetic methodologies for the syntheses and study of biologically important compounds such as antibiotics, antifungals and anticancer agents. Among his accomplishments are over 270 publications, 22 patents, and over 200 invited lectures. He also has directed graduate research for 77 students, most at the doctoral level.
1) When did you realize you wanted to be a scientist and, more specifically, what led you to focus on organic chemistry? My science teachers in my high school (Assumption Abbey – a Benedictine monastery in Western North Dakota) really kindled my interest. My chemistry teacher left a lot of information open that my classmates and I questioned and then my physics teacher, Fr. David, was awesome and filled us with the wonders of how and why things work from the atomic level on up. Then, my sophomore year at North Dakota State, my organic teacher, Socrates Peter Pappas, came into the lab after the first lecture exam and assigned most of us to research groups. He picked me and gave me an independent project. When I showed him the results of an early experiment that, based on our 60 MHz NMR, worked surprisingly well, he was so excited that I was hooked on chemistry forever.
2) What is your favorite organic reaction and why? My favorite organic reaction is the Lossen rearrangement since it converts an acid (carboxylic acid) into a base (amine) using the chemistry of hydroxamic acids. Hydroxamic acids are amazingly versatile compounds that we have used to make bioactive compounds for nearly every therapeutic area from antibiotics to anti-inflammatory agents, anti-cancer agents, microbial iron transport agents, drug delivery systems and more.
3) What do you consider the grand challenge in synthetic organic/medicinal chemistry? Keeping mankind one step ahead in combating diseases, especially the never ending war on infection. Antibiotics are responsible for more than half of the more than 50% increase in life span in the last three generations. Nothing, absolutely nothing, in science or medicine has had such a dramatically positive influence on humanity. Unfortunately, antibiotic resistance is evolving rapidly and there is inadequate support for new discovery efforts. The fear that we will return to a preantibiotic era is not unrealistic.
4) You've been at Notre Dame for 35 years, so it's safe to say you like it here. Could you elaborate on what you like best about ND? Without a doubt the best parts of ND are the students and colleagues. Our students at all levels are, for the most part, genuinely good people, interested in learning, not just for their own benefit but with good intentions to help others.
5) If you could have dinner with any three people of the past or the present, who would they be? My extended family. I wish so much that my children, their spouses and my grandchildren could all share a meal and extended time with Patty, me and our now deceased parents to share the many thoughts, and experiences and wisdom from our ancestors. I would also really like to have a dinner event with all the students, postdocs, research associates, collaborators and other coworkers I have had together with my mentors (Prof. Socrates Peter Pappas at North Dakota State University, Prof. G. Marc Loudon, at Cornell, now at Purdue, and Prof. Henry Rapoport (dec) at UC Berkeley).
Of course I would love to have dinner with some of the early pioneers in chemistry and especially antibiotic science all together to get a broader perspective on how they were able to accomplish so much without all the amazing analytical instrumentation we have today. Finally, I would really like to have dinner with Christ to ask him how, while on this earth, he could convert water (non-organic molecule) into wine that contains ethanol (an organic, two carbon containing molecule).
6) Of what professional accomplishment are you proudest? Mentoring about 80 Ph.D.s, more than 60 postdocs and research associates and countless undergraduates, while learning so much together.
7) Organic chemists are people too. What does Professor Miller do to relax? Actually, I would really love to be able to spend time working in the lab myself rather than just enjoying learning vicariously with my coworkers. The most relaxing moments I have are with my family, my wife Patty, our four (now grown) children, their spouses and our 6 grandsons (all age 4 and under, including triplets!). Though I have not taken enough time for them, I also enjoy hiking, swimming (though it is still so hard), golfing (once or twice a year only unfortunately), fly fishing and woodworking (I built most of the furniture in our house while our children were growing up). “Work” is also not always work as I enjoy discussions and interactions with colleagues and collaborators from around the world at meetings and still get excited about every new molecule I learn about.
A research team led by the University of Notre Dame is working to cut the test time for disease biomarkers.
Summer research is underway for the students awarded fellowships from Notre Dame’s Center for Nano Science and Technology (NDnano).
Sofia Carozza, College of Science neuroscience and behavior major, with a supplemental major in theology, asks her classmates if they will say "yes" to putting their learning in the service of justice.
The work Notre Dame neuroscience and behavior students do in the community benefits both them and the organizations they serve, inspiring hope and skills in all people to take part in changing communities for the better.
Matthew Webber, assistant professor of chemical and biomolecular engineering at the University of Notre Dame, has been named a recipient of the 2019 3M Non-tenured Faculty Award.
Building a close-knit scientific research community at Notre Dame is one of the reasons the College of Science Joint Annual Meeting (COS-JAM) is so popular, according to Xuemin (Sheryl) Lu, director of undergraduate research.
Not only was Sofia Carozza, class of 2019 valedictorian and neuroscience and behavior major, unsure what her major would be when she stepped onto the Notre Dame campus as a freshman, but she was even hesitant about majoring in science at all. Her curiosity about the world and interest in brain science, however, allowed her to overcome her fears.
The conference will convene thought leaders from the private sector, international NGOs, foundations, academia and local, state and federal governments to delve into topics such as smart cities and urban innovation.
Sylwia Ptasinska, associate professor of physics, published research in Physical Review Letters that begins to explain how low-energy electrons cause damage to DNA and proteins, molecules of life. She and her collaborators selected three formamide molecules to serve as models for proteins.