HCRI Lecture: "Steering cancer evolution: Harnessing phenotypic heterogeneity to design better combination therapies"


Location: 1st Source Auditorium, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend


Alexander Anderson
Chair, Integrated Mathematical Oncology Department
Moffitt Cancer Center
Tampa, Florida

"Steering Cancer Evolution: Harnessing Phenotypic Heterogeneity to Design Better Combination Therapies"

Alexander Anderson, Ph.D. performed his doctoral work on hybrid mathematical models of nematode movement in heterogeneous environments at the Scottish Crop Research Institute in Dundee, UK. His postdoctoral work was on hybrid models of tumor-induced angiogenesis with Prof. Mark Chaplain at Bath University, UK. He moved back to Dundee in 1996 where he worked for the next 12 years on developing mathematical models of many different aspects of tumor progression and treatment, including anti-angiogenesis, radiotherapy, tumor invasion, evolution of aggressive phenotypes and the role of the microenvironment. He is widely recognized as one of only a handful of mathematical oncologists that develops truly integrative models that directly impact upon biological experimentation. His pioneering work using evolutionary hybrid cellular automata models has led to new insights into the role of the tumor microenvironment in driving tumor progression. Due to his belief in the crucial role of mathematical models in cancer research he moved his group to the Moffitt Cancer Center in 2008 to establish the Integrated Mathematical Oncology department.

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