Professor of Developmental Biology, Virginia and Daniel K. Ludwig Professor of Cancer Research
Investigator, Howard Hughes Medical Institute, Stanford University
A major focus of the Nusse lab is Wnt signaling, which is essential for regulating stem cells. How this is achieved is far from clear and is the subject of studies in the lab, both in vivo and in cell culture. The types of questions that the Nusse lab investigates are: What role do Wnt-responsive cells play in tissue maintenance and regeneration? How is the expression of Wnt signals regulated, in normal and injured tissues? Does oriented Wnt signaling polarize asymmetrically dividing stem cells, which plays a central role in tissue homeostasis and regeneration.